Small-Molecule Inhibition of BRDT for Male Contraception
نویسندگان
چکیده
منابع مشابه
Small-Molecule Inhibition of BRDT for Male Contraception
A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling...
متن کاملBrdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.
Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the s...
متن کاملMale Contraception
Very few options for men to initiate fertility control are currently available. Due to the potential public health impact of a novel method of contraception for men in the developed and developing world, a number of organizations are conducting or supporting studies which focus on the male contraceptive aspect of reproductive health. These include bilateral and multilateral donors, national gov...
متن کامل[Male contraception].
Clear evidence shows that many men and women would welcome new male methods of contraception, but none have become available. The hormonal approach is based on suppression of gonadotropins and thus of testicular function and spermatogenesis, and has been investigated for several decades. This approach can achieve sufficient suppression of spermatogenesis for effective contraception in most men,...
متن کاملSmall Molecule Inhibition of RISC Loading
Argonaute proteins are the core components of the microRNP/RISC. The biogenesis and function of microRNAs and endo- and exo- siRNAs are regulated by Ago2, an Argonaute protein with RNA binding and nuclease activities. Currently, there are no in vitro assays suitable for large-scale screening of microRNP/RISC loading modulators. We describe a novel in vitro assay that is based on fluorescence po...
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ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.06.045